Uvéite et bisphosphonates

Uvéite antérieure révélatrice d'une sarcoïdose

Il s'agit d'une patiente âgée de 40 ans, antécédents de rougeur oculaire à répétition en niveau des deux yeux et qui présente depuis une semaine un 'il gauche rouge douloureux avec baisse d'acuité visuelle. L'examen ophtalmologique retrouve une acuité visuelle à 3/10 au niveau de l'œil gauche et 8/10 au niveau de l'œil droit. A la lampe à fente, on trouve au niveau de l'œil gauche des précipité...

Intravenous bisphosphonates in osteoporosis and jaw osteonecrosis: comment on the article by Delmas et al.

Antitumor activity of bisphosphonates.

Introduction Bone metastases are a major cause of morbidity for patients with many types of cancer including multiple myeloma, breast cancer, prostate cancer, and other solid tumors. The clinical complications of bone metastases include pain, fracture, spinal cord compression, and hypercalcemia of malignancy. Although there are important differences in the biology of bone metastases from differ...

Bisphosphonates: mechanisms of action.

T bisphosphonates have been known to chemists since the middle of the 19th century, when the first synthesis occurred in 1865 in Germany (1). Etidronate, the first bisphosphonate to be used to treat a human disease (2), was synthesized exactly 100 yr ago (3). Bisphosphonates were used in industry, mainly as corrosion inhibitors or as complexing agents in the textile, fertilizer, and oil industr...

Disambiguating the bisphosphonates.

The bisphosphonates comprise a class of therapeutic agents that inhibit bone resorption and are frequently used in medicine in the treatment of among others osteoporosis, skeletal metastases from solid tumours, hypercalcaemia of malignancy, multiple myeloma and Paget’s disease [1]. First synthesised in 1865 in Germany, their use had been primarily industrial as these molecules proved to be powe...